期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 159, 期 7, 页码 702-706出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwh090
关键词
clinical trials; cohort studies; logistic regression; Mantel-Haenszel; odds ratio; relative risk
Relative risk is usually the parameter of interest in epidemiologic and medical studies. In this paper, the author proposes a modified Poisson regression approach (i.e., Poisson regression with a robust error variance) to estimate this effect measure directly. A simple 2-by-2 table is used to justify the validity of this approach. Results from a limited simulation study indicate that this approach is very reliable even with total sample sizes as small as 100. The method is illustrated with two data sets.
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