期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 10, 期 7, 页码 1711-1715出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200305551
关键词
carbohydrates; combinatorial chemistry; concanavalin A; glycoconjugates; receptors
Dynamic combinatorial chemistry (DCC) has emerged as an efficient approach to receptor/ligand identification based on the generation of combinatorial libraries by reversible interconversion of the library constituents. In this study, the implementation of such libraries on carbohydrate-lectin interactions was examined with the plant lectin Concanavalin A as a target species. Dynamic carbohydrate libraries were generated from a pool of carbohydrate aldehydes and hydrazide linker/scaffold components through re- versible acylhydrazone exchange, resulting in libraries containing up to 474 constituents. Dynamic deconvolution allowed the efficient identification of the structural features required for binding to Concanavalin A and the selection of a strong binder, a tritopic mannoside, showing an IC50-value of 22 mum.
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