期刊
BRAIN RESEARCH
卷 1003, 期 1-2, 页码 188-193出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2003.11.050
关键词
paradoxical sleep deprivation; behavioral sensitization; amphetamine; open-field behavior; conditioning
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [98/14303-3] Funding Source: FAPESP
The effects of paradoxical sleep deprivation (PSD-48 h) on the conditioned and unconditioned components of behavioural sensitization to amphetamine (two injections of 2.0 mg/kg, separated by 7 days) were studied using locomotion frequency of mice observed in an open-field as experimental parameter. Behavioural sensitization only occurred in PS deprived mice that were exposed to the open-field after the first amphetamine injection. The possible involvement of PSD in the development of a Pavlovian association between the stimulant effect of amphetamine and environmental as well as interoceptive drug cues is discussed. (C) 2004 Elsevier B.V. All rights reserved.
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