期刊
SCIENCE
卷 304, 期 5667, 页码 108-110出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1095004
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资金
- NCRR NIH HHS [RR00163] Funding Source: Medline
- NIDDK NIH HHS [DK55819, DK65900] Funding Source: Medline
- NINDS NIH HHS [NS37952] Funding Source: Medline
In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus (ARH). Here, we report that neural projection pathways from the ARH are permanently disrupted in leptin-deficient (Lep(ob)/Lep(ob)) mice and leptin treatment in adulthood does not reverse these neuroanatomical defects. However, treatment of Lep(ob)/Lep(ob) neonates with exogenous leptin rescues the development of ARH projections, and leptin promotes neurite outgrowth from ARH neurons in vitro. These results suggest that leptin plays a neurotrophic role during the development of the hypothalamus and that this activity is restricted to a neonatal critical period that precedes leptin's acute regulation of food intake in adults.
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