期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 10, 期 7, 页码 1677-1682出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200305582
关键词
alkenes; biomimetic synthesis; electrophilic addition; halogenation; water chemistry
An efficient protocol to synthesize iodohydrins from alkenes is presented. Reactions were conducted in aqueous media using safe and readily available sodium iodide (the most abundant form of the element), and a highly convenient oxidant such as hydrogen peroxide. Addition of a protic acid triggers a faster and efficient process, a role formally related to that played by haloperoxidase enzymes in naturally occurring transformations. The successful application of these conditions to multigram scale preparations and over natural products derivatives is also discussed.
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