Stably-dispersed and surface-functional bionanoparticles prepared by self-assembling amphipathic polymers of hydrophilic poly(γ-glutamic acid) bearing hydrophobic amino acids

Surface-functional bionanoparticles were prepared by self-assembling amphipathic poly(gamma-glutamic acid) derivatives with a hydrophilic backbone and hydrophobic phenylalanine and leucine side groups. Poly(gamma-glutamic acid) bearing phenylalanine nanospheres exhibited excellent water-dispersibility. surface functionality and appropriate size (200 inn) for medical use. Additive PEG conjugation assisted nanoparticle formation Of leucine-grafted poly(gamma-glutamic acid).