期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 8, 页码 1889-1892出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm049938j
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资金
- NIAID NIH HHS [AI 053247] Funding Source: Medline
- NIGMS NIH HHS [GM 61964] Funding Source: Medline
Aza-peptide Michael acceptors are a new class of irreversible inhibitors that are highly potent and specific for clan CD cysteine proteases. The aza-Asp derivatives were specific for caspases, while aza-Asn derivatives were effective legumain inhibitors. Aza-Lys and aza-Orn derivatives were potent inhibitors of gingipain K and clostripain. Aza-peptide Michael acceptors showed no cross reactivity toward papain, cathepsin B, and calpain.
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