期刊
NEUROSCIENCE LETTERS
卷 359, 期 1-2, 页码 13-16出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.neulet.2003.12.123
关键词
neurogenesis; hippocampus; spatial learning; cell survival; adult; rat
Neuron production carries on throughout adult life in granule cell layer of mammalian dentate gyrus. The acquisition of a hippocampus-dependent task enhances newborn cell survival in granule cell layer (GCL) during the period in which several newborn cells die. In this paper the effect of learning, occurring after the maximal period of newborn cell death, on newborn cells was investigated. Rats were trained for hippocampus-dependent learning in Morris water maze. 5-bromo-2'-deoxyuridine was administered 8-10 days before training beginning and labeled cells were counted after training. Learning decreased BrdU-Iabeled cell density in GCL, and increased TUNEL-positive cells. Moreover, learning diminished immature neuron density prevalently in the internal blade of GCL. Therefore, a different effect of learning on immature neuron survival, depending on the time elapsing from mitosis to learning, is suggested. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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