期刊
BRAIN RESEARCH
卷 1004, 期 1-2, 页码 198-202出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2004.01.018
关键词
cerebral ischemia; 5-lipoxygenase; knockout mouse; leukotriene
Cerebral ischemia induces 5-lipoxygenase translocation and leukotriene production in the brain. We tried to clarify the pathological significance of 5-lipoxygenase on cerebral ischemia using 5-lipoxygenase knockout mice. No significant difference was observed in the infarct size following permanent and transient ischemia for 60 min between both types of mice. The present study did not support the idea that leukotriene production is involved in infarct expansion in focal cerebral ischemia. (C) 2004 Elsevier B.V. All rights reserved.
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