期刊
FEBS LETTERS
卷 563, 期 1-3, 页码 165-169出版社
WILEY
DOI: 10.1016/S0014-5793(04)00291-1
关键词
plant mitochondrion; cytochrome c biogenesis; gene expression; RNA editing; blue native
In land plant mitochondria, c-type cytochromes are assembled via a mechanism similar to that found in Gram-negative bacteria and different from that used by mitochondria from other eukaryotes. The wheat mitochondrial genome encodes CCM (for cytochrome c maturation) proteins, among them CcmF(C), a protein similar to the C-terminal part of the bacterial CcmF. The gene is transcribed into a 1.7 kb transcript at steady state. However, the 3' termini of the transcript were found to occur upstream of the deduced gene termination codon. This discrepancy was solved by RNA editing that introduces a novel termination codon, thus shortening the reading frame by 27 codons. The processed transcript is translated into a protein integrated in the mitochondrial inner membrane. We also show that the protein is part of a large (700 kDa) protein complex, that possibly represents a cytochrome c assembly complex. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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