期刊
FEBS LETTERS
卷 563, 期 1-3, 页码 13-16出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(04)00233-9
关键词
collagen; monocyte; carbamylation; matrix metalloproteinase-9; atherosclerosis; tissue inhibitor of metalloproteinase-1
Carbamylation refers to chemical modification of protein side chains by cyanate derived e.g. from urea. It alters their structural and functional properties. We have studied the influence of the carbamylation of type I collagen in vitro on its interactions with elutriated human monocytes, and its potential role in atherosclerosis. Adhesion of monocytes onto carbamylated collagen was significantly enhanced compared to native collagen. There was no change in superoxide anion production. On the other hand, there was an increase in the production and the activation of matrix metalloproteinase-9. No effect was found on tissue inhibitor of metalloproteinase-1 production Thus, the presence of carbamylated collagen may stimulate the remodelling of extracellular matrix mediated by activated monocytes. Such alterations may contribute to enhanced atherosclerosis in renal insufficiency, a pathological condition associated with elevated levels of carbamylation. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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