期刊
NEUROREPORT
卷 15, 期 5, 页码 781-784出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200404090-00008
关键词
circadian rhythm; development; embryonic; light entrainment; melanopsin; PACAP; photoreceptor; retina; retinal ganglion cells; retinohypothalamic tract
There is accumulating evidence that the new opsin-like protein, melanopsin, in adult rodents functions as non-visual photoreceptor. Here we report using immunohistochemistry and in situ hybridisation that melanopsin during rat retinal development is expressed already at prenatal day 18 in cells of the inner neuroblast layer. Perinatally the melanopsin positive cells increase in number and migrate towards the ganglion cell layer. During early postnatal development a melanopsin immunoreactive dendritic network is formed in the inner plexiform layer. Melanopsin is exclusively expressed in PACAP-containing cells which in adults become the retinal ganglion cells constituting the retinohypothalamic tract. The early expression of melanopsin argues for a photoreceptor role in the developing retinohypothalamic tract which is functional as early as the first day after birth.
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