期刊
FEBS LETTERS
卷 563, 期 1-3, 页码 219-222出版社
WILEY
DOI: 10.1016/S0014-5793(04)00286-8
关键词
ribosome-inactivating protein; lectin; adenine polynucleotide glycosylase; protein synthesis
Ribosome-inactivating proteins (RIPs) display adenine polynucleotide glycosylase activity on different nucleic acid substrates, which at the ribosomal level is responsible for the arrest of protein synthesis. Some type 2 RIPs, namely ricin and related proteins, are extremely toxic to mammalian cells and animals whilst other type 2 RIPs (non-toxic type 2 RIPs) display three to four logs less toxicity. We studied whether a correlation exists between toxicity on cells and enzymatic activity on nucleic acids. All type 2 RIPs differ in their depurinating activity on the different substrates with differences of up to one to two logs. The toxicity of type 2 RIPs is independent of their enzymatic activity on nucleic acids or on ribosomes. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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