期刊
JOURNAL OF CELL BIOLOGY
卷 165, 期 1, 页码 27-30出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200311091
关键词
neurodegeneration; synapse function; Wallerian degeneration; polyubiquitination; monoubiquitination
类别
The ubiquitin proteasome system (UPS) contributes to the pathophysiology of neurodegenerative diseases, and it is also a major determinant of synaptic protein degradation and activity. Recent studies in rodents and in the fruit fly Drosophila have shown that the activity of the UPS is involved in axonal degeneration. Increased knowledge of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of neuronal injuries and neurodegenerative disorders.
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