期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 15, 页码 5417-5420出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0307136101
关键词
asymmetric catalysis; alkynylzinc additions; propargylic alcohols
资金
- NIGMS NIH HHS [R01 GM058454, R01GM58454] Funding Source: Medline
It is found that the addition of hexamethylphosphoramide to the solution of an alkyne, Et2Zn, and (S)-1,1'-bi-2-naphthol in methylene chloride allows the generation of an alkynylzinc at room temperature and shows highly enantioselective additions to aldehydes. The mild condition for the formation of the alkynylzinc reagent enables the use of functional alkynes in this asymmetric reaction with excellent enantioselectivity. It avoids the reflux of the toluene solutions of the alkynes and Et2Zn as previously reported.
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