期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 15, 页码 5542-5546出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0307247101
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资金
- NHLBI NIH HHS [HL38113, R01 HL038113] Funding Source: Medline
- NIAMS NIH HHS [AR47906, P01 AR047906] Funding Source: Medline
Myosin V, a double-headed molecular motor, transports organelles within cells by walking processively along actin, a process that requires coordination between the heads. To understand the mechanism underlying this coordination, processive runs of single myosin V molecules were perturbed by varying nucleotide content. Contrary to current views, our results show that the two heads of a myosin V molecule communicate, not through any one mechanism but through an elaborate system of cooperative mechanisms involving multiple kinetic pathways. These mechanisms introduce redundancy and safeguards that ensure robust processivity under differing physiologic demands.
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