期刊
JOURNAL OF IMMUNOLOGY
卷 172, 期 8, 页码 4672-4675出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.172.8.4672
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- NIAID NIH HHS [AI42332, AI35914] Funding Source: Medline
There are conflicting reports on the requirements for the IL-27-WSX-1 pathway in the development of Th type 1 responses and resistance to intracellular pathogens, although early IFN-gamma production and resistance to Leishmania major are impaired. in the absence of WSX-1 signaling, WSX-1(-/-) mice generate robust IFN-gamma responses and control infection with other intracellular protozoan pathogens. In this report, we resolve these conflicting observations and demonstrate that, in the absence of IL-4, WSX-1 is not required for early IFN-gamma production and control of L. major. Thus, the requirement for WSX-1 signaling in Th type I cell differentiation,is restricted to conditions in which IL-4 is produced.
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