期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 12, 期 8, 页码 1853-1858出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.01.041
关键词
prodrug; self-immolative; enzyme; cancer
A new controlled drug delivery system for selective chemotherapy was developed. It is based on a chemical adaptor unit, that releases a drug by a spontaneous cyclization mechanism after cleavage of an enzymatic substrate. It also provides a generic linkage of a drug with a targeting device in a manner set to be triggered by defined enzymatic activity. The system is generic and allows using a variety of drugs, targeting devices, and enzymes by introducing the corresponding substrate as a trigger for drug release in the chemical adaptor. (C) 2004 Elsevier Ltd. All rights reserved.
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