期刊
BIOLOGICAL PSYCHIATRY
卷 55, 期 8, 页码 868-870出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2003.12.009
关键词
hippocampus; maternal separation; stress; depressive disorder; dentate gyrus
Background: There is a long-standing clinical awareness of the significance of adverse early experiences and subsequent stress in the evolution of psychiatric disorder. Methods: We investigated the impact of a single episode of preweaning maternal separation on in vivo electrophysiologic responses in the hippocampus of the mature rat after repeated exposure to an open elevated platform. Results: Only rats that bad experienced both maternal separation followed by stressful platform exposure when mature bad significantly increased granule cell response to perforant path stimulation, compared with control rats. Rats exposed to either maternal separation or the elevated platform in adulthood alone did not differ significantly from control rats. Conclusions: Adverse early experience seems to induce functional changes in the hippocampus that remain latent until activated by stress in adulthood. Such electrophysiologic changes might represent a neural substrate for vulnerability to stress-associated psychopathology.
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