期刊
SCIENCE
卷 304, 期 5669, 页码 445-448出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1093139
关键词
-
资金
- NCRR NIH HHS [RR12305] Funding Source: Medline
- NICHD NIH HHS [HD07518] Funding Source: Medline
- NIGMS NIH HHS [GM07250] Funding Source: Medline
Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common host background (C57BL/6J). A survey of 53 traits revealed evidence for 150 QTLs affecting serum levels of sterols and amino acids, diet-induced obesity, and anxiety. These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据