期刊
LIFE SCIENCES
卷 74, 期 22, 页码 2769-2779出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2003.10.020
关键词
oleanolic acid; ursolic acid; cytochrome P450; microsomes; herbal medicine
Oleanolic acid (OA) and ursolic acid (UA), triterpene acids having numerous pharmacological activities including, anti-inflammatory, anti-cancer, and hepato-protective effects, were tested for their ability to modulate the activities of several cytochrome P450 (CYP) enzymes using human liver microsomes. OA competitively inhibited CYP1A2-catalyzed phenacetin O-deethylation and CYP3A4-catalyzed midazolam 1-hydroxylation, the major human drug metabolizing CYPs, with IC50 (K-i) values of 143.5 (74.2) muM and 78.9 (41.0) muM, respectively. UA competitively inhibited CYP2CI9-catalyzed S-mephenytoin 4'-hydroxylation with an IC50 (K-i) value of 119.7 (80.3) muM. However, other CYPs tested showed no or weak inhibition by both OA and UA. The present study demonstrates that OA and UA have inhibitory effects on CYP isoforms using human liver microsomes. It is thus likely that consumption of herbal medicines containing OA or UA, or administration of OA or UA, can cause drug interactions in humans when used concomitantly with drugs that are metabolized primarily by CYP isoforms. In addition, it appears that the inhibitory effect of OA on CYP1A2 is, in part, related to its anti-inflammatory and anticancer activities. (C) 2004 Elsevier Inc. All rights reserved.
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