期刊
MACROMOLECULAR BIOSCIENCE
卷 4, 期 4, 页码 383-398出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200300079
关键词
biomaterials; peptides; proteins; structure-property relations; supramolecular structures
The conjugation peptides/proteins and synthetic polymers is a useful strategy to overcome some of the limitations related to the use of the individual components. This review will highlight two aspects: enhanced structural control at the nanometer level and improved performance, in particular with respect to biomedical applications. In the former case, peptide sequences are mainly used to mediate I self-assembly of synthetic polymers. In the latter case, conjugation of an appropriate synthetic polymer to a pharmaceutically active peptide/protein can, for example, prevent premature enzymatic degradation and enhance blood circulation times, which is therapeutically advantageous.
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