期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 56, 期 6, 页码 885-899出版社
ELSEVIER
DOI: 10.1016/j.addr.2003.09.008
关键词
gut-associated lymphoid tissue; Peyer's patches; sheep; scrapie; prion; transmissible spongiform encephalopathies
Scrapie is a transmissible spongiform encephalopathy (TSE) and its spread across the intestine of sheep is linked to the biology of intestinal Peyer's patches (PPs). Specialized epithelial cells, M cells, would appear to be the portal of entry for the scrapie agent, PrPSc, while lymphoid nodules of PPs become major sites of accumulation of PrPSc as the infection becomes established. Furthermore, evidence suggests that the enteric nervous system supplying the PPs is important for neuroinvasion. The gut-associated lymphoid tissue (GALT) of ruminants shows morphological and functional differences to the GALT of mice and humans. Recent investigations of aging scrapie-affected sheep revealed a substantial network of nerve fibres in the lymphoid nodules of PPs, contradicting the widely held notion that lymphoid nodules are poorly innervated. Advances in the understanding of the pathogenesis of scrapie may be achieved by a deeper appreciation of the development, morphology and function of GALT in small ruminants. (C) 2004 Elsevier B.V. All rights reserved.
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