期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 8, 页码 1897-1900出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.02.081
关键词
addiction; acetylcholine
资金
- NIDA NIH HHS [DA 11940] Funding Source: Medline
- NINDS NIH HHS [NS 31669] Funding Source: Medline
Consideration of the activation and desensitization properties of neuronal nicotinic acetylcholine receptors (nAChRs) predicts that there should be a range of concentrations over which low ambient levels of agonist can continuously open nAChR channels. These findings support the idea that postsynaptic nAChRs may participate in unconventional cellular signaling mediated by the release of acetylcholine from diffusely distributed non-synaptic cholinergic varicosities. (C) 2004 Elsevier Ltd. All rights reserved.
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