期刊
BRITISH JOURNAL OF CANCER
卷 90, 期 8, 页码 1591-1593出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6601747
关键词
k-ras; MYH; colorectal adenoma; G : C -> T : A mutations; G12C
类别
Colorectal tumours from MYH polyposis patients display an excess of somatic G:C-->T:A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.005). G:C-->T:A transversions in k-ras were significantly more frequent in MYH polyposis adenomas than in sporadic or familial adenomatous polyposis-associated tumours (Pless than or equal to0.002), and all resulted in a glycine-to-cysteine substitution at codon 12.
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