期刊
ONCOGENE
卷 23, 期 18, 页码 3145-3150出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1207550
关键词
P3k; Akt; translation; TOR; TSC; Rheb; Raptor; YB-1
The induction and maintenance of oncogenic transformation requires interference with the controls that regulate translation and transcription. The PI 3-kinase pathway, which shows gain of function in numerous and diverse human cancers, generates signals that have a positive effect on the initiation of protein synthesis. Here we review the components of the PI 3-kinase signaling pathway and the mRNA-binding protein YB-1, exploring their roles in protein synthesis and oncogenic cell transformation.
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