期刊
JOURNAL OF NEUROSCIENCE
卷 24, 期 16, 页码 3917-3925出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5053-03.2004
关键词
prefrontal; frontal; inferior; temporal; cortex; lobes; frontopolar; anterior; dorsolateral; ventrolateral; episodic; associative; working; visual; memory; long term; short term; executive; control; fMRI; neuroimaging; event related
资金
- NCI NIH HHS [P01 CA095616] Funding Source: Medline
- NIA NIH HHS [R37 AG009253, AG05863, R01 AG015793, R01 AG009253, AG15793, AG09253, F32 AG005863] Funding Source: Medline
- NIMH NIH HHS [R01 MH063901, MH63901] Funding Source: Medline
- NINDS NIH HHS [NS40813, P01 NS040813] Funding Source: Medline
Higher order cognition depends on the ability to recall information from memory and hold it in mind to guide future behavior. To specify the neural mechanisms underlying these processes, we used event-related functional magnetic resonance imaging to compare brain activity during the performance of a visual associative memory task and a visual working memory task. Activity within category-selective subregions of inferior temporal cortex reflected the type of information that was actively maintained during both the associative memory and working memory tasks. In addition, activity in the anterior prefrontal cortex and hippocampus was specifically enhanced during associative memory retrieval. These data are consistent with the view that the active maintenance of visual information is supported by activation of object representations in inferior temporal cortex, but that goal-directed associative memory retrieval additionally depends on top-down signals from the anterior prefrontal cortex and medial temporal lobes.
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