期刊
BRAIN RESEARCH
卷 1006, 期 1, 页码 1-7出版社
ELSEVIER
DOI: 10.1016/j.brainres.2003.12.049
关键词
hypothalamic paraventricular nucleus; thyrotropin-releasing hormone; cocaine- and amphetamine-regulated transcript; phenylethanolamine N-methyltransfemse; adrenergic neuron; colocalization
资金
- FIC NIH HHS [TW01494] Funding Source: Medline
- NIDDK NIH HHS [DK37021] Funding Source: Medline
Cocaine- and amphetamine-regulated transcript (CART)-IR axons densely innervate the thyrotropin-releasing hormone (TRH) neurons in the hypothalamic paraventricular nucleus (PVN), partly arising from neuronal perikarya in the hypothalamic arcuate nucleus. The source of the remaining CART innervation, however, is unknown. We have recently demonstrated that neurons co-containing adrenaline and CART in the C1-3 areas of the medulla project to the PVN. Since adrenergic neurons densely innervate the hypophysiotropic TRH neurons, we raised the possibility that adrenergic neurons contribute to the CART-IR innervation of hypophysiotropic TRH neurons. Combined in situ hybridization and immunocytochemistry was performed to study the colocalization of CART and phenylethanolamine N-methyltransferase (PNMT), the synthesizing enzyme of adrenaline, in axons innervating the hypophysiotropic TRH neurons. PNMT was observed in 44% of CART-IR axons in juxtaposition to the hypophysiotropic TRH neurons and CART-IR was observed in approximately 50% of all PNMT axons in contact with proTRH perikarya in the PVK. We conclude that adrenergic neurons of the medulla give rise to approximately half of the CART-IR axons innervating hypophysiotropic TRH neurons in the PVN, and propose that CART may play important role in the modulation of adrenergic input to the hypothalamic-pituitary-thyroid axis. (C) 2004 Elsevier B.V. All rights reserved.
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