期刊
FEBS LETTERS
卷 564, 期 1-2, 页码 9-13出版社
WILEY
DOI: 10.1016/S0014-5793(04)00356-4
关键词
cancer; human telomerase reverse transcriptase; oncoprotein; telomerase; tumor suppressor
资金
- NCI NIH HHS [CA085257, R01 CA085257] Funding Source: Medline
Telomere attrition limits the replicative potential of most somatic cells. In contrast, tumor cells acquire immortality by continuous telomere maintenance which is predominantly due to the transcriptional upregulation of the limiting component of telomerase, hTERT (human telomerase reverse transcriptase). Recent findings have provided mechanistic insight into how oncogenic activation as well as derepression, often due to the inactivation of tumor suppressors, stimulate the hTERT promoter. Knowledge gained from the study of hTERT transcriptional regulation may prove instrumental in the development of cancer therapies directed at the suppression of telomerase activity in tumor cells. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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