Nanoflow system for perfect regiocontrol in the Baeyer-Villiger oxidation by aqueous hydrogen peroxide using lowest concentration of a fluorous lanthanide catalyst

The scandium bis(perfluorooctanesulfonyl)amide-catalyzed Baeyer-Villiger reaction significantly increased the regioselectivity as well as the reaction rate by nanoflow system continuously controlled by a nanofeeder even in the lowest concentration of the catalyst (much less than0.1 mol %), The Baeyer-Villiger reaction completed within few seconds as a contact time in the microcell to afford the lactone products high regioselectively without hydrolysis. (C) 2004 Elsevier Ltd. All rights reserved.