期刊
FEBS LETTERS
卷 564, 期 3, 页码 239-244出版社
WILEY
DOI: 10.1016/S0014-5793(04)00242-X
关键词
mitochondrial carrier; electron crystallography; X-ray crystallography; structure; membrane protein
资金
- Medical Research Council [MC_U105663139] Funding Source: Medline
- MRC [MC_U105663139] Funding Source: UKRI
Members of the mitochondrial carrier family transport compounds over the inner mitochondrial membrane to link the biochemical pathways in the cytosol with those in the mitochondrial matrix. X-ray crystallography has recently provided us with the first atomic model of the bovine ADP/ATP carrier, which is a member of this family. The structure explains the typical three-fold sequence repeats and signature motif of mitochondrial carriers. However, the carrier was crystallised as a monomer in detergent, which is inconsistent with the consensus that mitochondrial carriers exist as homo-dimers. The projection structure of the yeast ADP/ATP carrier by electron crystallography shows that carriers could form homo-dimers in the membrane. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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