期刊
SCIENCE
卷 304, 期 5671, 页码 743-746出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1094561
关键词
-
资金
- NIGMS NIH HHS [GM61034, GM38511] Funding Source: Medline
A general caging method for proteins that are regulated by phosphorylation was used to study the in vivo biochemical action of cofilin and the subsequent cellular response. By acute and local activation of a chemically engineered, light-sensitive phosphocofilin mimic, we demonstrate that cofilin polymerizes actin, generates protrusions, and determines the direction of cell migration. We propose a role for cofilin that is distinct from its role as an actin-depolymerizing factor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据