期刊
EJSO
卷 30, 期 4, 页码 414-420出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejso.2004.01.013
关键词
hepatocellular carcinoma; hepatic resection; recurrence; prognostic factors; survival
Aim. The prognosis of patients with recurrent hepatocellular carcinoma (HCC) after hepatic resection varies widely. This study analyzed Long-term survival and prognostic factors of patients with recurrent HCC after hepatectomy. Methods. From July 1991 to December 2000, 623 patients underwent hepatic resection for HCC. Of those, 347 (56.5%) patients had tumour recurrence, and 286 patients with follow-up time more than 24 months after recurrence were enrolled. Twenty-seven clinicopathologic factors underwent both univariate and multivariate analysis. Results. Of these 286 patients, survival times after tumour recurrence were mean 672 +/- 619 days; median 468 days; and, range 10-3753 days. The overall 1-, 3-, 5-, and 10-year post-recurrence survival rates were 61.5, 33.4, 18.2, and 9.0%, respectively. Seventy (24.5%) patients were alive at the time of study, and 10 of the 34 patients who underwent re-resection were disease-free. By Cox regression analysis, multiple initial tumours (relative risk (RR) 1.428), recurrent multiple (RR 1.372), extrahepatic recurrence (RR 2.434), recurrent tumour size >2 cm (RR 1.926), post-hepatectomy period until recurrence < 1 year (RR 1.769), and non-resectional, treatment of recurrent tumours (RR 3.527) were independent prognostic factors for post-recurrent survival rates. Conclusions. In patients with recurrent HCC after hepatectomy, both initial and recurrent tumour factors influenced their prognosis. Early detection of recurrent tumours is important. Re-resection correlated with better post-recurrent survival rates. (C) 2004 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据