期刊
JOURNAL OF CELL SCIENCE
卷 117, 期 11, 页码 2173-2181出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.01227
关键词
Rb/E2F; cell cycle; transcription repression; histone acetylation; histone methylation
类别
资金
- NCI NIH HHS [CA64402] Funding Source: Medline
- NIGMS NIH HHS [GM53203] Funding Source: Medline
Alterations in transcription of genes regulated by members of the E2F family of transcription factors can be viewed as a measure of the ebb and flow in a constantly evolving battle between repressor and activator complexes. Various chromatin regulatory complexes have been linked to Rb/E2F proteins, and changes in histone modifications correlate with states of E2F-dependent transcription. E2F has traditionally been viewed in the context of cell-cycle control. However, several recent studies have revealed a new aspect of E2F function in which pRB/E2F-family proteins confer stable repression of transcription. Such repression is evident in both actively proliferating cells and in cells that have withdrawn from the cell cycle.
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