期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 48, 期 5, 页码 1900-1903出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.5.1900-1903.2004
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资金
- NHLBI NIH HHS [R01 HL064851, HL64851] Funding Source: Medline
- NIAID NIH HHS [AI042371] Funding Source: Medline
The human cytomegalovirus (HCMV) homolog of the Epstein-Barr virus (EBV) protein kinase (PK), UL97, is inhibited by maribavir (1263W94) and selected indolocarbazoles. Here we show that only one of these indolocarbazoles (K252a), but not maribavir, inhibits autophosphorylation of the EBV PK, BGLF4. However, maribavir and another indolocarbazole, NGIC-I, do inhibit EBV DNA synthesis, suggesting that although these last compounds inhibit both HCMV and EBV, they seem to operate through different pathways.
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