期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 19, 期 5, 页码 811-822出版社
WILEY
DOI: 10.1359/JBMR.040119
关键词
matrix metalloproteinases; extracellular matrix; osteoblast function; low bone turnover; mouse model
Mice specifically overexpressing TIMP-1 in osteoblasts have been generated to investigate the role of MMPs in bone in vivo. These mice displayed increased trabecular bone volume and decreased bone turnover. This model provides evidence of the role played by the MMPs in bone remodeling and balance.
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