期刊
HUMAN IMMUNOLOGY
卷 65, 期 5, 页码 500-506出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2004.02.012
关键词
CMV; immune response; T cells; HIV; monitoring
类别
A large percentage of healthy individuals (50-9%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of the current strategies to identify CMV-specific T cells are centered on the assessment of the functions of memory T cells including their ability to mediate effector function, to proliferate or to secrete cytokines following antigen-specific stimulation. The investigation of these functions has allowed the characterization of the CMV-specific T-cell responses that are present during different phases of the infection. Furthermore, it has also been shown that the combination of virus-specific CD4 and CD8 T-cell responses are critical components of the immune response in the control of virus replication. Human Immunology 65, 500-506 (2004). (C) American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc.
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