Selective localization of active proteins to patterns or specific sites is important for development of biosensors, bioMEMS, tissue engineering, and basic proteomic research. We present a flexible technique for selectively patterning bioactive proteins with nanoscale resolution using nanoimprint lithography and fluoropolymer surface passivation, and exploiting the specificity of the biotin/streptavidin linkage. This technique achieves high throughput reproducible nanoscale protein patterns with high selectivity and retained biofunctionality, as demonstrated by interactions between patterned antibodies and their antigen.
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