期刊
JOURNAL OF VIROLOGY
卷 78, 期 9, 页码 4907-4913出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.9.4907-4913.2004
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We investigated the in vitro RNA dimerization properties of the untranslated leader RNA derived from human immunodeficiency virus type 1 variants circulating in an individual with a low viral load and slow disease progression. The leader sequences of these viruses contain highly unusual polymorphisms within the dimerization initiation site (DIS): an insert that abolishes dimerization and a compensatory substitution. The dimerization of leader RNA from late stages of infection is further improved by additional mutations outside the DIS motif that facilitate a secondary structure switch from a dimerization-incompetent to a dimerization-competent RNA conformation.
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