Effect of storage temperatures and time on the efficacy of multipurpose solutions for contact lenses

Purpose: To determine the effect of storage time and temperature on the efficacy of four multipurpose solutions for soft contact lenses. Method: Aliquots of multipurpose solutions (OPTI-FREE Express, ReNu MultiPlus, COMPLETE and SOLO-care) stored at different temperatures over a 3-month period, were challenged with contact lens-related ocular pathogens, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. Results: The results showed that OPTI-FREE Express had the best activity against Ps. aeruginosa at all temperatures; ReNu MultiPlus performed well at 25 C; COMPLETE barely achieved activity requirements at all temperatures, and lost efficacy after 2 months. SOLO-care maintained its activity best against Ps. aeruginosa at 30 C. Storage at fridge temperature reduced activity of all solutions. Regardless of storage temperature, activities of all solutions against S. aureus markedly decreased by 2 months. Only OPTI-FREE Express met FDA requirements against C. albicans. Conclusion: Performance of multipurpose solutions is affected by time and temperature of storage. Contact lens users should be aware that the efficacy of opened solutions may not be sustained for as long as 3 months. Manufacturers should reconsider their recommendations to further safeguard the ocular health of contact lens wearers.