期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 34, 期 5, 页码 1483-1487出版社
WILEY
DOI: 10.1002/eji.200324736
关键词
CpG DNA; B lymphocyte; Th1/Th2 cell; gene rearrangement; cellular differentiation
类别
资金
- NIAID NIH HHS [AI01803, AI057471] Funding Source: Medline
Unmethylated CpG-containing DNA plays a critical role in immunity via the augmentation of Th1 but suppression of Th2 T cell responses. We describe here that CpG motifs also redirect isotype production by murine B cells to Th1-like Ig isotypes (IgG2a, IgG2b, and IgG3) while suppressing Th2 isotypes (IgG1 and IgE). Using genetically mutant B cells, we find that the IgG2a, IgG2b and IgG3 isotypes are transcriptionally regulated via the promotion of class-switching, in a manner critically dependent upon TLR9 and MyD88. Thus, CpG DNA redirects Ig isotype production by regulating the specificity of class-switch recombination.
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