期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 19, 期 5, 页码 610-616出版社
WILEY
DOI: 10.1002/jmri.20043
关键词
kidney; BOLD MRI; reproducibility; oxygenation; furosemide; water diuresis
资金
- NIDDK NIH HHS [R01 DK053221, R01 DK053221-07, DK 53221] Funding Source: Medline
Purpose: To estimate the reproducibility of BOLD MRI measurements in the evaluation of intrarenal oxygenation levels. Materials and Methods: In this study, the reproducibility of semiquantitative BOLD MRI measurements performed on a 1.5 T scanner with a multiple gradient-echo sequence in the renal medulla and cortex, and their response to furosemide and waterload, were assessed in eight healthy young subjects (25.6 +/- 4.1 years). Each subject underwent an identical experimental procedure on two separate days. Results: Renal R-2* measurements were shown to be reproducible within similar to12% from day to day based on a coefficient of variance (CV) analysis. The changes in R-2* (DeltaR(2)*) following administration of furosemide were statistically significant, as shown by ANOVA and a paired Student's t-test, and were deemed reliable based on the reliable change index (RCI). However, DeltaR(2)* values following waterload were not statistically significant, and were not deemed reliable. Conclusion: R2* measurements were reproducible over 270 days within 12%. Furosemide produced a significant and reliable change (similar to30%), and the magnitude of change (5.7 s(-1)) was reproducible and consistent with our previous data. The response to waterload, however, did not reach statistical significance, and the magnitude did not reach the level that we had previously reported.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据