期刊
ENVIRONMENTAL RESEARCH
卷 95, 期 1, 页码 77-81出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2003.10.007
关键词
micronuclei (MN); polychromatic erythrocytes (PCE); mouse bone marrow; municipal landfill leachate; genotoxic agent
The induction of micronuclei (MN) in polychromatic erythrocytes (PCE) of mouse bone marrow by municipal landfill leachate was studied in vivo. Results showed that mouse exposure via drinking water containing various concentrations of leachate caused a significant increase of MN frequencies in a concentration (Chemical oxygen demand measured with potassium dichromate oxidation CODCr)-dependent manner. MN induction in female and male mice was different at higher concentrations. This implies that leachate is a genotoxic agent in mammalian cells and that exposure to leachate in an aquatic environment may pose a potential genotoxic risk to human beings. (C) 2003 Elsevier Inc. All rights reserved.
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