期刊
BIOMATERIALS
卷 25, 期 10, 页码 1929-1936出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2003.08.023
关键词
micelle; thermally responsive material; pH responsive material; drug delivery; synthesis
A one-pot synthesis of an amphiphilic oleic acid-end capped random poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) (2) is reported. In aqueous media, the solubility of 2 was temperature- and pH-sensitive. Both the lower critical solution temperature and critical micelle concentration (CMC) of 2 were pl-I-dependent. The LCST of 2 was around 35.2degreesC in acidic buffer solutions (pH = 2.00-5.00), and it was increased significantly to around 38.4degreesC in neutral and alkaline buffer solutions (pH 7.00-11.00). Polymer 2 exhibited a phase transition pH around 6.7, below which the polymer became significantly less water-soluble. The CMC of 2 was 40 mg/l in pH 2.0 buffer solution, and it was increased markedly to 60-67 mg/l in pH 7.0 and pH 11.0 buffer solutions. Micelle solutions of 2 in different pH conditions were prepared by a membrane-dialysis method. In aqueous solution, dynamic light scattering studies revealed that the size of micelles was 50-90 nm with the particle size being larger in acidic solutions. In solid state, transmission electron microscope studies showed that micelles were roughly spherical, their sizes were 25-90 nm and it decreased with the increase of solution pH. The pH-sensitivity of 2 was triggered by the -COOH in the hydrophobic segment. The temperature- and pH-sensitivity of the novel polymeric micelles would make an interesting drug delivery system. (C) 2003 Elsevier Ltd. All rights reserved.
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