期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 53, 期 5, 页码 696-699出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkh162
关键词
resource-constrained countries; drug users; protease inhibitors; non-nucleoside reverse transcriptase inhibitors; public health
资金
- NIMH NIH HHS [R01 MH054907] Funding Source: Medline
Public health debates about providing HIV antiretroviral therapy to impoverished populations have centred on the relationship between adherence and risk of drug resistance. Recent data indicate that each antiretroviral therapeutic class has a unique adherence-resistance relationship. Resistance to single protease inhibitor therapy occurs most frequently at moderate to high levels of adherence, resistance to non-nucleoside reverse transcriptase inhibitor therapy occurs at low to moderate levels of adherence, and resistance to ritonavir-boosted protease inhibitor therapy is most likely to occur at middle ranges of adherence. These dynamic relationships should be considered in balancing the individual and public health benefits of therapy.
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