期刊
EUROPEAN HEART JOURNAL
卷 25, 期 9, 页码 778-786出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.ehj.2004.02.006
关键词
breastfeeding; infant nutrition; cardiovascular disease; ischaemic heart disease; systematic review
Aims To investigate the association of breastfeeding with all-cause, cardiovascular and ischaemic heart disease mortality. Methods and results A long-term follow-up of 4999 children originally surveyed from 1937 to 1939 was undertaken (Boyd Orr cohort). Four thousand three hundred and seventy-nine subjects (88%) were traced in adulthood and 3555 (71%) had complete data on all covariates. The results were combined with a meta-analysis of the published Literature. In the Boyd Orr study, there was little evidence that breastfeeding was associated with all-cause (hazard ratio: 1.04 [95% Cl: 0.90-1.20]), cardiovascular (1.04 [0.83-1.30]), or ischaemic heart disease (1.02 [0.77-1.36]) mortality, compared with bottle-feeding. Meta-analyses of observational studies showed little evidence of an association of breastfeeding with all-cause (pooled rate ratio: 1.01 [95% Cl: 0.91-1.13]) or cardiovascular (1.06 [0.94-1.20]) mortality. There was a moderate-to-high degree of between-study heterogeneity for the association between breastfeeding and ischaemic heart disease mortality (11 value-indicating the degree of between-study variation attributable to heterogeneity-66%), and estimates were consistent with both an important beneficial or adverse effect of breastfeeding. Conclusion There is little consistent evidence that breastfeeding influences subsequent all-cause or cardiovascular disease mortality. Results from other well-designed cohorts may clarify residual uncertainty. (C) 2004 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.
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