Growth of large single crystals of the orthorhombic paracetamol

A new procedure for the growth of large (cm-range) single crystals of the metastable orthorhombic (s.g. Pcab) polymorph of paracetamol is described. The crystals were grown by very slow cooling of hot water solutions under the conditions, when the multiple nucleation was prevented. The samples were characterized by DSC and X-ray diffraction. (C) 2004 Elsevier B.V. All rights reserved.