期刊
BIOMACROMOLECULES
卷 5, 期 3, 页码 846-851出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm034215n
关键词
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资金
- NIGMS NIH HHS [R01-GM-61232] Funding Source: Medline
At a specific temperature, elastin-like polypeptides (ELPs) undergo a sharp solubility transition that can be exploited in a variety of applications in biotechnology and medicine. The temperature of the transition varies with ELP sequence, molecular weight, and concentration. We present a single equation of three parameters that quantitatively predicts the transition temperature as a function of ELP length and concentration for an ELP of a fixed composition. This model should be useful both for the design of new ELP sequences that exhibit a desired transition temperature and for the selection of variables to trigger the phase transition of an ELP for a given application.
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