期刊
INFECTION AND IMMUNITY
卷 72, 期 5, 页码 2989-2994出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.5.2989-2994.2004
关键词
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资金
- NIAID NIH HHS [AI 43558, R01 AI043558, R21 AI069156] Funding Source: Medline
- NIAMS NIH HHS [AR 07107, P30 AR041942, R01 AR010493, AR 48513, AR 10493, T32 AR007107] Funding Source: Medline
During natural infection with the agent of Lyme disease, Borrelia burgdorferi, spirochetes are delivered with vector saliva, which contains anti-inflammatory and antihemostatic activities. We show here that the saliva of ixodid ticks reduces polymorphonuclear leukocyte (PMN) adhesion via downregulation of beta2-integrins and decreases the efficiency of PMN in the uptake and killing of spirochetes. Inhibition of integrin adhesion and signaling reduces anti-inflammatory functions of PMN. These effects may favor the initial survival of spirochetes in vivo.
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