期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 19, 期 5, 页码 722-727出版社
WILEY
DOI: 10.1359/JBMR.040113
关键词
thalassemia; osteoporosis; hypogonadism; osteoprotegerin; RANKL
Osteoporosis represents an important cause of morbidity in adult thalassemic patients, and its pathogenesis has not, as yet, been completely clarified. In our study, we observed that thalassemic patients showed a significantly lower OPG/RANKL ratio than normal subjects. These data are extremely important for the possible therapeutic use of RANKL antagonists such as OPG in thalassemia-induced osteoporosis.
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